Lesson 5 · Other Designs and Approaches to Know · Step 1 of 7
N-of-1 studies
When trial evidence says one treatment is better on average but your patient seems to do worse on it, an N-of-1 study compares conditions within that one person over time. Measure at baseline, introduce the treatment, withdraw it, reintroduce it, and see whether the outcome moves only when the treatment is present. Staggering start dates across several people replicates the test. In Eldoret, Kenya, nine fathers with problem drinking started a lay-counselor intervention at random times, and the odds of an alcohol-free day rose about fivefold after treatment.
Also covered: single-case designs · withdrawal and reversal · multiple baseline designs · carryover and washout
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Lesson 5 · 7 steps
Research Designs · lesson 5 of 5